- Stan Marsh
Most of the events in South Park evolve around Stan. He is known for making fun of Cartman's weight and he likes Wendy Testeburger.
- Kyle Broslofski
Kyle is Jewish and has a little brother named Ike. He seems to be friends with Stan, because they are usually together.
- Eric Cartman
Cartman is overweight. When he whines to his mom, she is quick to do whatever he wants. His trademark saying is: Beefcake!
- Kenny McKormick
Kenny always wears his hood over his mouth so his words are muffled. The viewers can not understand what he is saying, however, the characters on the show do. Every episode (except the Christmas one) he is killed and always comes back to life.
- Chef
Chef is the cook at the school's cafeteria and the kids look up to him. He enjoys singing sexually explicit music.
- Mr. Garrison
Mr. Garrison is the kid's teacher. He has a "feminine" quality about him and once tried to shoot Kathy Lee Gifford.
- Mr. Hat
Mr. Hat is Mr. Garrison's hand-puppet. Mr. Garrison has conversations with Mr. Hat. Mr. Hat was the one who encouraged Mr. Garrison to try to kill Kathy Lee Gifford.
- Officer Barbrady
Officer Barbrady is a police officer in South Park. He never notices what is going on and does his job poorly.
- Wendy Testeburger
Wendy is a perfect student. She likes Stan and is always trying to get his attention.
- Clyde
Clyde is a student in class.
- Bebe
Bebe is Wendy's best friend and is usually with her.
- Mr. Broslofski
Kyle's dad. He's a Rabbi.
- Halfy
Halfy doesn't have any legs, making it impossible for him to be screwed.
- Jesus
He's the son of God, and he has his own public access t.v. call in show called "Jesus & Pals".
- Mr. McKormick
This is Kenny's dad. He's poor and this is because he is always drunk.
- Kevin
Kevin the Monkey Boy is Maphesto's sidekick.
- Kitty
Kitty is always trying to take Cartman's food.
- Maphesto
South Park's mad scientist.
- Mr. Mackee
Mr. Mackee is the school's guidance counslor and once had a drug habit.
- Priest
The Preacher in South Park.
- Principal Victoria
The School's principal.
- Ike Broslofski
Ike is Kyle's little brother. He is shaped like a football and is always getting kicked.
- Mrs. Cartman
Mrs. Cartman is Eric's mother. She is quick to spoil him and do whatever he says. Mrs. Cartman has been on the cover of 'Crack Whore' magazine.
- Mrs. Crabtree
Mrs. Crabtree is the school bus driver. She is cruel and is a bad driver. She gets made fun of by the boys and she does not realize it.
- Shelley Marsh
Shelly is Stan's evil older sister. She is always mean and she picks on Stan.
- Jimbo
Jimbo is Stan's uncle. He is the owner of a local gun shop. He enjoys hunting and beer.
- Ned
Ned has cancer so he talks with a voice symthesizer. It makes him sound computerized.
- Randy Marsh
Randy is Stan's father. He is the seismologist of South Park and once saved the town from a volcanic eruption.
- Mayor
The Mayor of South Park graduated from Princeton. She cares more about her own image then the welfare of the city.

- Terrence + Phillip
Terrence and Phillip is a cartoon that the kids in South Park watch. It is a very funny cartoon that has a lot of farting in it.